Thousands of protesters went from their encampment near the Government House to Prime Minister´s residence in downtown Bangkok.
Around 15-hundred police were deployed to keep security around the premier´s house as the protesters poured some 50 litres of onated blood.
They called the donations a "symbolic shedding of blood for democracy".
The protesters collected the blood by asking each supporter to donate.
Some demonstrators poured blood onto the gates and fences of the house, while others hurled bags and bottles of blood inside the compound.
Abhisit has not been staying at his house and has been working out of a military base in Bangkok since Friday.
The blood protest was meant to increase pressure on the government to dissolve the parliament and hold elections.
The demonsrtators are mainly supporters of ousted prime minister Thaksin Shinawatra.
The billionaire, former Prime Minister has been convicted of corruption, and lives in self-imposed exile outside the country.